Hippocampal nitric oxide contributes to sex difference in affective behaviors
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چکیده
منابع مشابه
Hippocampal nitric oxide contributes to sex difference in affective behaviors.
Mechanisms underlying the female preponderance in affective disorders are poorly understood. Here we show that hippocampal nitric oxide (NO) plays a role in the sex difference of depression-like behaviors in rodents. Female mice had substantially lower NO production in the hippocampus and were significantly more likely to display negative affective behaviors than their male littermates. Elimina...
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Abstract: Introduction: Nitric oxide (NO) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. Previous studies revealed that hippocampal pyramidal cells contain NO synthase (NOS) enzyme which produce NO and could be a promising target to evaluate the role of NO in brain cognitive functions. So in this study, using NOS inhibitor (L-NAME)...
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Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains a high density of NMDA receptors and...
متن کاملthe role of hippocampal nitric oxide in passive avoidance learning
abstract: introduction: nitric oxide (no) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. previous studies revealed that hippocampal pyramidal cells contain no synthase (nos) enzyme which produce no and could be a promising target to evaluate the role of no in brain cognitive functions. so in this study, using nos inhibitor (l-name),...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1207461109